Senior E Conference - 2021/2022
League Secretary:
Chris Barrett
| Sunday, 14 November 2021 |
| Kendal Senior U18 Colts | 36 | 0 | Southport Senior U18 Colts |
| Newcastle (Staffs) Senior U18 Colts | 57 | 7 | Preston Grasshoppers Senior U18 Colts |
| Sunday, 21 November 2021 |
| Recovery Week | v | Preston Grasshoppers Senior U18 Colts |
| Southport Senior U18 Colts | 7 | 33 | Newcastle (Staffs) Senior U18 Colts |
| Sunday, 28 November 2021 |
| Kendal Senior U18 Colts | v | Recovery Week |
| Preston Grasshoppers Senior U18 Colts | 12 | 22 | Southport Senior U18 Colts |
| Sunday, 12 December 2021 |
| Recovery Week | v | Southport Senior U18 Colts |
| Kendal Senior U18 Colts | 22 | 19 | Newcastle (Staffs) Senior U18 Colts |
| Sunday, 23 January 2022 |
| Newcastle (Staffs) Senior U18 Colts | v | Recovery Week |
| Preston Grasshoppers Senior U18 Colts | 5 | 38 | Kendal Senior U18 Colts |
| Sunday, 30 January 2022 |
| Newcastle (Staffs) Senior U18 Colts | 34 | 5 | Southport Senior U18 Colts |
| Preston Grasshoppers Senior U18 Colts | v | Recovery Week |
| Sunday, 13 February 2022 |
| Recovery Week | v | Kendal Senior U18 Colts |
| Southport Senior U18 Colts | 0 | 0 | Preston Grasshoppers Senior U18 Colts |
| Sunday, 20 February 2022 |
| Southport Senior U18 Colts | v | Recovery Week |
| Sunday, 27 February 2022 |
| Recovery Week | v | Newcastle (Staffs) Senior U18 Colts |
| Kendal Senior U18 Colts | 22 | 10 | Preston Grasshoppers Senior U18 Colts |
| Sunday, 6 March 2022 |
| Preston Grasshoppers Senior U18 Colts | 22 | 24 | Newcastle (Staffs) Senior U18 Colts |
| Southport Senior U18 Colts | 10 | 38 | Kendal Senior U18 Colts |
| Sunday, 13 March 2022 |
| Newcastle (Staffs) Senior U18 Colts | 24 | 14 | Kendal Senior U18 Colts |