| Wednesday, 25 August 2021 |
| Colts League AGM |
| Sunday, 29 August 2021 |
| Bank Holiday |
| Sunday, 5 September 2021 |
| Preliminary Week 1 |
| Transition Week | v | Bolton Senior U18 Colts |
| Crewe & Nantwich Senior U18 Colts | 28 | 19 | Newcastle (Staffs) Senior U18 Colts |
| Rochdale Senior U18 Colts | 27 | 12 | Preston Grasshoppers Senior U18 Colts |
| Sunday, 12 September 2021 |
| Preliminary Week 2 |
| Crewe & Nantwich Senior U18 Colts | v | Transition Week |
| Newcastle (Staffs) Senior U18 Colts | 46 | 19 | Rochdale Senior U18 Colts |
| Preston Grasshoppers Senior U18 Colts | 17 | 13 | Bolton Senior U18 Colts |
| Sunday, 19 September 2021 |
| Preliminary Week 3 |
| Transition Week | v | Preston Grasshoppers Senior U18 Colts |
| Bolton Senior U18 Colts | 7 | 12 | Newcastle (Staffs) Senior U18 Colts |
| Rochdale Senior U18 Colts | 21 | 45 | Crewe & Nantwich Senior U18 Colts |
| Sunday, 26 September 2021 |
Lancashire Cup Round 1
Cheshire Transition Week |
| Sunday, 3 October 2021 |
| Preliminary Week 4 |
| Crewe & Nantwich Senior U18 Colts | Home Walkover | Bolton Senior U18 Colts |
| Newcastle (Staffs) Senior U18 Colts | 45 | 6 | Preston Grasshoppers Senior U18 Colts |
| Rochdale Senior U18 Colts | v | Transition Week |
| Sunday, 10 October 2021 |
| Transition Week |
| Sunday, 17 October 2021 |
| Preliminary Week 5 |
| Transition Week | v | Newcastle (Staffs) Senior U18 Colts |
| Bolton Senior U18 Colts | v | Rochdale Senior U18 Colts |
| Preston Grasshoppers Senior U18 Colts | 0 | 48 | Crewe & Nantwich Senior U18 Colts |
| Sunday, 24 October 2021 |
Lancashire Cup Round 2
Cheshire Transition Week |
| Sunday, 31 October 2021 |
| Transition Week |
| Sunday, 7 November 2021 |
| Transition Week |
| Sunday, 14 November 2021 |
| Conference Week 1 |
| Sunday, 21 November 2021 |
| Conference Week 2 |
| Sunday, 28 November 2021 |
| Conference Week 3 |
| Sunday, 5 December 2021 |
| Transition Week |
| Sunday, 12 December 2021 |
| Conference Week 4 |
| Sunday, 19 December 2021 |
| Transition Week |
| Sunday, 26 December 2021 |
| Xmas / New Year |
| Sunday, 2 January 2022 |
| Xmas / New Year |
| Sunday, 9 January 2022 |
| Transition Week |
| Sunday, 16 January 2022 |
Lancashire Cup QF
Cheshire Cup Round 1 |
| Sunday, 23 January 2022 |
| Conference Week 5 |
| Sunday, 30 January 2022 |
| Conference Week 6 |
| Sunday, 6 February 2022 |
Cheshire Cup Round 2
Lancashire Transition Week |
| Sunday, 13 February 2022 |
| Conference Week 7 |
| Sunday, 20 February 2022 |
| Conference Week 8 |
| Sunday, 27 February 2022 |
| Conference Week 9 |
| Sunday, 6 March 2022 |
| Conference Week 10 |
| Sunday, 13 March 2022 |
| League Cup R1 |
| Sunday, 20 March 2022 |
Lancashire Cup Semi Finals
Cheshire Cup Semi Finals |
| Sunday, 27 March 2022 |
| League Cup QTRs |
| Sunday, 3 April 2022 |
| League Cup Semi's |
| Sunday, 10 April 2022 |
| Transition Week |
| Sunday, 17 April 2022 |
| Easter |
| Sunday, 24 April 2022 |
Lancashire Cup Final
Cheshire Cup Final |
| Sunday, 1 May 2022 |
| League Cup Finals |