| Wednesday, 25 August 2021 |
| Colts League AGM |
| Sunday, 29 August 2021 |
| Bank Holiday |
| Sunday, 5 September 2021 |
| Preliminary Week 1 |
| Eccles Senior U18 Colts | 23 | 12 | Sale FC Senior U18 Colts |
| Rossendale Senior Colts U18 | 24 | 36 | Kirkby Lonsdale Senior U18 Colts |
| Sunday, 12 September 2021 |
| Preliminary Week 2 |
| Kirkby Lonsdale Senior U18 Colts | 36 | 12 | Eccles Senior U18 Colts |
| Rossendale Senior Colts U18 | Home Walkover | Southport Senior U18 Colts |
| Sunday, 19 September 2021 |
| Preliminary Week 3 |
| Altrincham Kersal Senior U18 Colts | 0 | 17 | Kirkby Lonsdale Senior U18 Colts |
| Eccles Senior U18 Colts | 26 | 22 | Rossendale Senior Colts U18 |
| Southport Senior U18 Colts | 17 | 22 | Sale FC Senior U18 Colts |
| Sunday, 26 September 2021 |
Lancashire Cup Round 1
Cheshire Transition Week |
| Sale FC Senior U18 Colts | 41 | 19 | Altrincham Kersal Senior U18 Colts |
| Sunday, 3 October 2021 |
| Preliminary Week 4 |
| Eccles Senior U18 Colts | 8 | 17 | Southport Senior U18 Colts |
| Kirkby Lonsdale Senior U18 Colts | 38 | 12 | Sale FC Senior U18 Colts |
| Rossendale Senior Colts U18 | 26 | 0 | Altrincham Kersal Senior U18 Colts |
| Sunday, 10 October 2021 |
| Transition Week |
| Southport Senior U18 Colts | 40 | 12 | Altrincham Kersal Senior U18 Colts |
| Sunday, 17 October 2021 |
| Preliminary Week 5 |
| Altrincham Kersal Senior U18 Colts | 7 | 7 | Eccles Senior U18 Colts |
| Sale FC Senior U18 Colts | 22 | 26 | Rossendale Senior Colts U18 |
| Southport Senior U18 Colts | 3 | 24 | Kirkby Lonsdale Senior U18 Colts |
| Sunday, 24 October 2021 |
Lancashire Cup Round 2
Cheshire Transition Week |
| Sunday, 31 October 2021 |
| Transition Week |
| Sunday, 7 November 2021 |
| Transition Week |
| Sunday, 14 November 2021 |
| Conference Week 1 |
| Sunday, 21 November 2021 |
| Conference Week 2 |
| Sunday, 28 November 2021 |
| Conference Week 3 |
| Sunday, 5 December 2021 |
| Transition Week |
| Sunday, 12 December 2021 |
| Conference Week 4 |
| Sunday, 19 December 2021 |
| Transition Week |
| Sunday, 26 December 2021 |
| Xmas / New Year |
| Sunday, 2 January 2022 |
| Xmas / New Year |
| Sunday, 9 January 2022 |
| Transition Week |
| Sunday, 16 January 2022 |
Lancashire Cup QF
Cheshire Cup Round 1 |
| Sunday, 23 January 2022 |
| Conference Week 5 |
| Sunday, 30 January 2022 |
| Conference Week 6 |
| Sunday, 6 February 2022 |
Cheshire Cup Round 2
Lancashire Transition Week |
| Sunday, 13 February 2022 |
| Conference Week 7 |
| Sunday, 20 February 2022 |
| Conference Week 8 |
| Sunday, 27 February 2022 |
| Conference Week 9 |
| Sunday, 6 March 2022 |
| Conference Week 10 |
| Sunday, 13 March 2022 |
| League Cup R1 |
| Sunday, 20 March 2022 |
Lancashire Cup Semi Finals
Cheshire Cup Semi Finals |
| Sunday, 27 March 2022 |
| League Cup QTRs |
| Sunday, 3 April 2022 |
| League Cup Semi's |
| Sunday, 10 April 2022 |
| Transition Week |
| Sunday, 17 April 2022 |
| Easter |
| Sunday, 24 April 2022 |
Lancashire Cup Final
Cheshire Cup Final |
| Sunday, 1 May 2022 |
| League Cup Finals |