| Saturday, 6 September 2025 |
| Aldwinians 3rd XV | v | Manchester 3rd XV |
| Ashton-Under-Lyne 2nd XV | v | Knutsford |
| Congleton 2nd XV | v | Old Bedians 2nd XV |
| Dukinfield 2nd XV | v | Buxton RUFC |
| East Manchester RUFC 1st XV Men | v | Didsbury Toc H 3rd XV |
| Eccles RFC 4th XV | v | Wythenshawe |
| Saturday, 13 September 2025 |
| Aldwinians 3rd XV | v | Eccles RFC 4th XV |
| Didsbury Toc H 3rd XV | v | Congleton 2nd XV |
| Knutsford | v | East Manchester RUFC 1st XV Men |
| Manchester 3rd XV | v | Buxton RUFC |
| Old Bedians 2nd XV | v | Dukinfield 2nd XV |
| Wythenshawe | v | Ashton-Under-Lyne 2nd XV |
| Saturday, 4 October 2025 |
| Ashton-Under-Lyne 2nd XV | v | Aldwinians 3rd XV |
| Buxton RUFC | v | Old Bedians 2nd XV |
| Congleton 2nd XV | v | Knutsford |
| Dukinfield 2nd XV | v | Didsbury Toc H 3rd XV |
| East Manchester RUFC 1st XV Men | v | Wythenshawe |
| Eccles RFC 4th XV | v | Manchester 3rd XV |
| Saturday, 11 October 2025 |
| Aldwinians 3rd XV | v | East Manchester RUFC 1st XV Men |
| Didsbury Toc H 3rd XV | v | Buxton RUFC |
| Eccles RFC 4th XV | v | Ashton-Under-Lyne 2nd XV |
| Knutsford | v | Dukinfield 2nd XV |
| Manchester 3rd XV | v | Old Bedians 2nd XV |
| Wythenshawe | v | Congleton 2nd XV |
| Saturday, 18 October 2025 |
| Ashton-Under-Lyne 2nd XV | v | Manchester 3rd XV |
| Buxton RUFC | v | Knutsford |
| Congleton 2nd XV | v | Aldwinians 3rd XV |
| Dukinfield 2nd XV | v | Wythenshawe |
| East Manchester RUFC 1st XV Men | v | Eccles RFC 4th XV |
| Old Bedians 2nd XV | v | Didsbury Toc H 3rd XV |
| Saturday, 25 October 2025 |
| East Manchester RUFC 1st XV Men | v | Aldwinians 3rd XV |
| Saturday, 8 November 2025 |
| Aldwinians 3rd XV | v | Dukinfield 2nd XV |
| Ashton-Under-Lyne 2nd XV | v | East Manchester RUFC 1st XV Men |
| Eccles RFC 4th XV | v | Congleton 2nd XV |
| Knutsford | v | Old Bedians 2nd XV |
| Manchester 3rd XV | v | Didsbury Toc H 3rd XV |
| Wythenshawe | v | Buxton RUFC |
| Saturday, 15 November 2025 |
| East Manchester RUFC 1st XV Men | v | Manchester 3rd XV |
| Saturday, 22 November 2025 |
| Buxton RUFC | v | Aldwinians 3rd XV |
| Congleton 2nd XV | v | Ashton-Under-Lyne 2nd XV |
| Didsbury Toc H 3rd XV | v | Knutsford |
| Dukinfield 2nd XV | v | Eccles RFC 4th XV |
| Old Bedians 2nd XV | v | Wythenshawe |
| Saturday, 29 November 2025 |
| Aldwinians 3rd XV | v | Old Bedians 2nd XV |
| Ashton-Under-Lyne 2nd XV | v | Dukinfield 2nd XV |
| East Manchester RUFC 1st XV Men | v | Congleton 2nd XV |
| Eccles RFC 4th XV | v | Buxton RUFC |
| Manchester 3rd XV | v | Knutsford |
| Wythenshawe | v | Didsbury Toc H 3rd XV |
| Saturday, 6 December 2025 |
| Buxton RUFC | v | Ashton-Under-Lyne 2nd XV |
| Congleton 2nd XV | v | Manchester 3rd XV |
| Didsbury Toc H 3rd XV | v | Aldwinians 3rd XV |
| Dukinfield 2nd XV | v | East Manchester RUFC 1st XV Men |
| Knutsford | v | Wythenshawe |
| Old Bedians 2nd XV | v | Eccles RFC 4th XV |
| Saturday, 13 December 2025 |
| Aldwinians 3rd XV | v | Knutsford |
| Ashton-Under-Lyne 2nd XV | v | Old Bedians 2nd XV |
| Congleton 2nd XV | v | Dukinfield 2nd XV |
| East Manchester RUFC 1st XV Men | v | Buxton RUFC |
| Eccles RFC 4th XV | v | Didsbury Toc H 3rd XV |
| Manchester 3rd XV | v | Wythenshawe |
| Saturday, 20 December 2025 |
| Buxton RUFC | v | Congleton 2nd XV |
| Didsbury Toc H 3rd XV | v | Ashton-Under-Lyne 2nd XV |
| Dukinfield 2nd XV | v | Manchester 3rd XV |
| Knutsford | v | Eccles RFC 4th XV |
| Old Bedians 2nd XV | v | East Manchester RUFC 1st XV Men |
| Wythenshawe | v | Aldwinians 3rd XV |
| Saturday, 10 January 2026 |
| Ashton-Under-Lyne 2nd XV | v | Wythenshawe |
| Buxton RUFC | v | Manchester 3rd XV |
| Congleton 2nd XV | v | Didsbury Toc H 3rd XV |
| Dukinfield 2nd XV | v | Old Bedians 2nd XV |
| Eccles RFC 4th XV | v | Aldwinians 3rd XV |
| Saturday, 17 January 2026 |
| Aldwinians 3rd XV | v | Ashton-Under-Lyne 2nd XV |
| Didsbury Toc H 3rd XV | v | Dukinfield 2nd XV |
| Knutsford | v | Congleton 2nd XV |
| Manchester 3rd XV | v | Eccles RFC 4th XV |
| Old Bedians 2nd XV | v | Buxton RUFC |
| Wythenshawe | v | East Manchester RUFC 1st XV Men |
| Saturday, 24 January 2026 |
| Ashton-Under-Lyne 2nd XV | v | Eccles RFC 4th XV |
| Buxton RUFC | v | Didsbury Toc H 3rd XV |
| Congleton 2nd XV | v | Wythenshawe |
| Dukinfield 2nd XV | v | Knutsford |
| Old Bedians 2nd XV | v | Manchester 3rd XV |
| Saturday, 31 January 2026 |
| East Manchester RUFC 1st XV Men | v | Knutsford |
| Saturday, 14 February 2026 |
| Aldwinians 3rd XV | v | Congleton 2nd XV |
| Didsbury Toc H 3rd XV | v | Old Bedians 2nd XV |
| Eccles RFC 4th XV | v | East Manchester RUFC 1st XV Men |
| Knutsford | v | Buxton RUFC |
| Manchester 3rd XV | v | Ashton-Under-Lyne 2nd XV |
| Wythenshawe | v | Dukinfield 2nd XV |
| Saturday, 28 February 2026 |
| Buxton RUFC | v | Wythenshawe |
| Congleton 2nd XV | v | Eccles RFC 4th XV |
| Didsbury Toc H 3rd XV | v | Manchester 3rd XV |
| Dukinfield 2nd XV | v | Aldwinians 3rd XV |
| East Manchester RUFC 1st XV Men | v | Ashton-Under-Lyne 2nd XV |
| Old Bedians 2nd XV | v | Knutsford |
| Saturday, 7 March 2026 |
| Aldwinians 3rd XV | v | Buxton RUFC |
| Ashton-Under-Lyne 2nd XV | v | Congleton 2nd XV |
| Eccles RFC 4th XV | v | Dukinfield 2nd XV |
| Knutsford | v | Didsbury Toc H 3rd XV |
| Manchester 3rd XV | v | East Manchester RUFC 1st XV Men |
| Wythenshawe | v | Old Bedians 2nd XV |
| Saturday, 21 March 2026 |
| Buxton RUFC | v | Eccles RFC 4th XV |
| Congleton 2nd XV | v | East Manchester RUFC 1st XV Men |
| Didsbury Toc H 3rd XV | v | Wythenshawe |
| Dukinfield 2nd XV | v | Ashton-Under-Lyne 2nd XV |
| Knutsford | v | Manchester 3rd XV |
| Old Bedians 2nd XV | v | Aldwinians 3rd XV |
| Saturday, 28 March 2026 |
| Aldwinians 3rd XV | v | Didsbury Toc H 3rd XV |
| Ashton-Under-Lyne 2nd XV | v | Buxton RUFC |
| East Manchester RUFC 1st XV Men | v | Dukinfield 2nd XV |
| Eccles RFC 4th XV | v | Old Bedians 2nd XV |
| Manchester 3rd XV | v | Congleton 2nd XV |
| Wythenshawe | v | Knutsford |
| Saturday, 11 April 2026 |
| Buxton RUFC | v | East Manchester RUFC 1st XV Men |
| Didsbury Toc H 3rd XV | v | Eccles RFC 4th XV |
| Dukinfield 2nd XV | v | Congleton 2nd XV |
| Knutsford | v | Aldwinians 3rd XV |
| Old Bedians 2nd XV | v | Ashton-Under-Lyne 2nd XV |
| Wythenshawe | v | Manchester 3rd XV |
| Saturday, 18 April 2026 |
| Aldwinians 3rd XV | v | Wythenshawe |
| Ashton-Under-Lyne 2nd XV | v | Didsbury Toc H 3rd XV |
| Congleton 2nd XV | v | Buxton RUFC |
| East Manchester RUFC 1st XV Men | v | Old Bedians 2nd XV |
| Eccles RFC 4th XV | v | Knutsford |
| Manchester 3rd XV | v | Dukinfield 2nd XV |
| Saturday, 25 April 2026 |
| Buxton RUFC | v | Dukinfield 2nd XV |
| Didsbury Toc H 3rd XV | v | East Manchester RUFC 1st XV Men |
| Knutsford | v | Ashton-Under-Lyne 2nd XV |
| Manchester 3rd XV | v | Aldwinians 3rd XV |
| Old Bedians 2nd XV | v | Congleton 2nd XV |
| Wythenshawe | v | Eccles RFC 4th XV |