| Wednesday, 25 August 2021 |
| Colts League AGM |
| Sunday, 29 August 2021 |
| Bank Holiday |
| Sunday, 5 September 2021 |
| Preliminary Week 1 |
| Liverpool St Helens Senior U18 Colts | 29 | 17 | Littleborough Senior U18 Colts |
| Sunday, 12 September 2021 |
| Preliminary Week 2 |
| Caldy Senior U18 Colts | Away Walkover | Wirral Senior U18 Colts |
| Littleborough Senior U18 Colts | Away Walkover | Bowdon Senior U18 Colts |
| Liverpool St Helens Senior U18 Colts | 12 | 17 | Manchester Senior U18 Colts |
| Sunday, 19 September 2021 |
| Preliminary Week 3 |
| Bowdon Senior U18 Colts | 0 | 14 | Liverpool St Helens Senior U18 Colts |
| Manchester Senior U18 Colts | 29 | 12 | Caldy Senior U18 Colts |
| Wirral Senior U18 Colts | 25 | 7 | Littleborough Senior U18 Colts |
| Sunday, 26 September 2021 |
Lancashire Cup Round 1
Cheshire Transition Week |
| Sunday, 3 October 2021 |
| Preliminary Week 4 |
| Bowdon Senior U18 Colts | 7 | 15 | Manchester Senior U18 Colts |
| Littleborough Senior U18 Colts | Home Walkover | Caldy Senior U18 Colts |
| Liverpool St Helens Senior U18 Colts | 26 | 19 | Wirral Senior U18 Colts |
| Sunday, 10 October 2021 |
| Transition Week |
| Bowdon Senior U18 Colts | Home Walkover | Caldy Senior U18 Colts |
| Manchester Senior U18 Colts | 10 | 26 | Wirral Senior U18 Colts |
| Sunday, 17 October 2021 |
| Preliminary Week 5 |
| Caldy Senior U18 Colts | 5 | 15 | Liverpool St Helens Senior U18 Colts |
| Manchester Senior U18 Colts | 12 | 19 | Littleborough Senior U18 Colts |
| Wirral Senior U18 Colts | Home Walkover | Bowdon Senior U18 Colts |
| Sunday, 24 October 2021 |
Lancashire Cup Round 2
Cheshire Transition Week |
| Sunday, 31 October 2021 |
| Transition Week |
| Sunday, 7 November 2021 |
| Transition Week |
| Sunday, 14 November 2021 |
| Conference Week 1 |
| Sunday, 21 November 2021 |
| Conference Week 2 |
| Sunday, 28 November 2021 |
| Conference Week 3 |
| Sunday, 5 December 2021 |
| Transition Week |
| Sunday, 12 December 2021 |
| Conference Week 4 |
| Sunday, 19 December 2021 |
| Transition Week |
| Sunday, 26 December 2021 |
| Xmas / New Year |
| Sunday, 2 January 2022 |
| Xmas / New Year |
| Sunday, 9 January 2022 |
| Transition Week |
| Sunday, 16 January 2022 |
Lancashire Cup QF
Cheshire Cup Round 1 |
| Sunday, 23 January 2022 |
| Conference Week 5 |
| Sunday, 30 January 2022 |
| Conference Week 6 |
| Sunday, 6 February 2022 |
Cheshire Cup Round 2
Lancashire Transition Week |
| Sunday, 13 February 2022 |
| Conference Week 7 |
| Sunday, 20 February 2022 |
| Conference Week 8 |
| Sunday, 27 February 2022 |
| Conference Week 9 |
| Sunday, 6 March 2022 |
| Conference Week 10 |
| Sunday, 13 March 2022 |
| League Cup R1 |
| Sunday, 20 March 2022 |
Lancashire Cup Semi Finals
Cheshire Cup Semi Finals |
| Sunday, 27 March 2022 |
| League Cup QTRs |
| Sunday, 3 April 2022 |
| League Cup Semi's |
| Sunday, 10 April 2022 |
| Transition Week |
| Sunday, 17 April 2022 |
| Easter |
| Sunday, 24 April 2022 |
Lancashire Cup Final
Cheshire Cup Final |
| Sunday, 1 May 2022 |
| League Cup Finals |